肿瘤瞭望消化时讯

2026 ESMO LBA重磅发布!消化道肿瘤领域研究抢先预览

肿瘤瞭望消化时讯
编者按:2026年欧洲肿瘤内科学会(ESMO)年会将于10月23~27日在西班牙马德里盛大召开,目前大会官网已经公布万众期待的LBA(Late‑Breaking Abstract,最新突破性摘要)完整列表。消化道肿瘤依旧是本届ESMO的热点板块,覆盖胃食管肿瘤、胆道肿瘤、结直肠癌、肝癌、胰腺癌、食管癌多个癌种,ADC新药、免疫联合方案、围手术期策略优化、AI辅助多学科决策、营养干预等方向均产出关键临床结果,同时多项来自中国的原创临床研究荣登LBA舞台,代表中国力量走向国际。本文对消化道肿瘤相关LBA按癌种分类整理,带大家提前一睹本届大会消化道领域的重磅看点。

胃食管肿瘤

摘要号:LBA7

英文标题:CLARITY-Gastric 01 (CG-01): a Phase 3 study of sonesitatug vedotin (Sone-Ve) in second or later-line (2L+) advanced or metastatic Claudin 18.2 (CLDN18.2) positive gastroesophageal carcinoma (GEC)

中文标题:CLARITY-Gastric 01(CG-01):Sonesitatug vedotin(Sone-Ve)二线及以上(2L+)治疗Claudin 18.2阳性晚期/转移性胃食管癌的Ⅲ期研究

讲者:徐瑞华|中山大学肿瘤防治中心

摘要号:LBA77

英文标题:Arcotatug tavatecan (IBI343/TAK-921) versus treatment of physician’s choice (TPC) in previously treated, advanced gastric or gastroesophageal junction adenocarcinoma (G/GEJA): First interim analysis of the randomized, open-label, phase 3, G-HOPE-001 study

中文标题:Arcotatug tavatecan(IBI343/TAK‑921)对比研究者选择方案用于经治晚期胃癌/胃食管结合部腺癌:随机开放标签Ⅲ期G-HOPE-001研究首次中期分析

讲者:Kohei Shitara|Kashiwa, Japan, Chiba

摘要号:LBA80

英文标题:Anbenitamab plus chemotherapy for previously treated HER2-positive gastric or gastroesophageal carcinomas (GC/GEJC): Updated overall survival (OS) analysis of KC-WISE

中文标题:安尼妥单抗联合化疗用于经治HER2阳性胃/胃食管癌:KC-WISE研究更新总生存期(OS)结果

讲者:徐建明|解放军总医院第一医学中心

摘要号:LBA81

英文标题:Four Months of Adjuvant XELOX versus Six Months in Stage II–IIIB Gastric Cancer — The LOMAC Randomized Trial

中文标题:Ⅱ~ⅢB期胃癌XELOX辅助化疗4个月对比6个月疗效:LOMAC随机临床研究

讲者:徐大志|复旦大学肿瘤医院

胆道肿瘤

摘要号:LBA8

英文标题:Ivonescimab plus chemotherapy versus durvalumab plus chemotheray as first-line treatment for advanced biliary tract cancer: a randomized, controlled, double- blinded, phase 3 trial (HARMONi-GI1)

中文标题:依沃西单抗联合化疗对比度伐利尤单抗联合化疗一线治疗晚期胆道癌:随机、对照、双盲Ⅲ期HARMONi-GI1研究

讲者:周俭|复旦大学附属中山医院

摘要号:LBA21

英文标题:Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and gallbladder carcinoma (ACTICCA-1 trial)

中文标题:吉西他滨联合顺铂辅助化疗对比标准治疗用于胆管癌及胆囊癌根治性切除术后:ACTICCA-1研究

讲者:Henning Wege|Hamburg, Germany

摘要号:LBA22

英文标题:OPTIMUM: A randomized phase 2 study of maintenance olaparib (Ola) with or without durvalumab (Durva) in DDR gene-mutated advanced biliary tract cancer (aBTC)

中文标题:OPTIMUM:DDR基因突变型晚期胆道癌采用奥拉帕利维持治疗联合/不联合度伐利尤单抗的随机Ⅱ期研究

讲者:Changhoon Yoo|Seoul, Republic of Korea, Songpa-gu

结直肠癌

摘要号:LBA18

英文标题:AI for Robust Decision Support for Multidisciplinary Colorectal Cancer Team Meetings

中文标题:人工智能为结直肠癌多学科会诊提供可靠临床决策支持

讲者:Shazad Ashraf|Birmingham, United Kingdom

摘要号:LBA29

英文标题:IROCAS: A randomized phase III trial of adjuvant treatment intensification with mFOLFIRINOX versus mFOLFOX6 in high-risk stage III (T4 and/or N2) colon cancer

中文标题:IROCAS:高危Ⅲ期(T4和/或N2)结肠癌mFOLFIRINOX强化辅助治疗对比mFOLFOX6的随机Ⅲ期研究

讲者:Jaafar Bennouna|Suresnes, France

摘要号:LBA30

英文标题:Omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) versus placebo after resection of colorectal cancer liver metastases (EMT2): A multicentre, double-blind, randomised phase 3 trial

中文标题:结直肠癌肝转移切除术后Omega-3多不饱和脂肪酸EPA对比安慰剂:多中心双盲随机Ⅲ期EMT2研究

讲者:Mark A. Hull|Leeds, United Kingdom

摘要号:LBA31

英文标题:Biweekly versus conventional trifluridine/tipiracil plus bevacizumab for refractory metastatic colorectal cancer: the pragmatic phase 3 PRABITAS trial

中文标题:双周方案对比常规方案三氟胸苷/替匹嘧啶联合贝伐珠单抗治疗难治性转移性结直肠癌:实用性Ⅲ期PRABITAS研究

讲者:Hiroya Taniguchi|Nagoya, Japan, Aichi

摘要号:LBA32

英文标题:Final overall survival results from CheckMate 8HW: nivolumab plus ipilimumab versus nivolumab or chemotherapy in MSI-H/dMMR metastatic colorectal cancer

中文标题:CheckMate 8HW最终总生存结果:纳武利尤单抗联合伊匹木单抗对比纳武利尤单抗单药或化疗用于MSI-H/dMMR转移性结直肠癌

讲者:Sara Lonardi|Padua, Italy

摘要号:LBA87

英文标题:Clinical Complete Response With Dostarlimab Monotherapy in dMMR/MSI-H Locally Advanced Rectal Cancer (LARC): First Results From the Global Registrational AZUR-1 Trial

中文标题:dMMR/MSI-H局部晚期直肠癌接受多塔利单抗单药治疗获得临床完全缓解:全球注册AZUR-1研究首次结果

讲者:Andrea Cercek|New York, United States of America, NY

肝细胞癌

摘要号:LBA48

英文标题:Liver function trajectory and post-progression outcomes in the Phase 3 EMERALD-3 study of tremelimumab (T) + durvalumab (D) ± lenvatinib (L) + transarterial chemoembolisation (TACE) in participants (pts) with embolisation-eligible hepatocellular carcinoma (eeHCC)

中文标题:可栓塞肝细胞癌患者中,tremelimumab(T)+度伐利尤单抗(D)±仑伐替尼(L)联合TACE的Ⅲ期EMERALD-3研究:肝功能轨迹及进展后结局

讲者:Masatoshi Kudo|Osaka, Japan

食管癌

摘要号:LBA78

英文标题:Active surveillance versus standard surgery after neoadjuvant chemoradiotherapy for oesophageal cancer: long-term results of a cluster-randomised controlled trial (SANO)

中文标题:食管癌新辅助放化疗后主动监测对比标准手术治疗:整群随机对照SANO研究长期随访结果

讲者:Sanjiv S. Gangaram-Panday |Rotterdam, Netherlands

胰腺癌

摘要号:LBA82

英文标题:Daraxonrasib, a RAS(ON) multi-selective inhibitor vs chemotherapy in previously treated metastatic pancreatic adenocarcinoma (mPDAC): Additional subgroup analyses from the Ph3 RASolute 302 study

中文标题:RAS(ON)多选择性抑制剂Daraxonrasib对比化疗用于经治转移性胰腺导管腺癌:Ⅲ期RASolute302研究补充亚组分析

讲者:Zev A. Wainberg |Los Angeles, United States of America

摘要号:LBA83

英文标题:Seven-Valent mKRAS-specific Lymph Node Targeted Amphiphile Immunotherapy Versus Observation in Resected Pancreatic Ductal Adenocarcinoma (PDAC): the AMPLIFY-7P randomized Phase 2 study

中文标题:七价mKRAS特异性淋巴结靶向两亲性免疫治疗与观察疗法在已切除胰腺导管腺癌中的疗效对比:AMPLIFY-7P随机Ⅱ期研究

讲者:Eileen M. O'Reilly|New York, United States of America

摘要号:LBA84

英文标题: A randomized, multicenter, open-label, double-arm, phase III study of doublet vs. monotherapy in advanced pancreatic cancer patients who have failed first-line therapy. (Panc-SELECT - Gemcitabine arms)

中文标题:一线治疗失败晚期胰腺癌,双药对比单药治疗的随机、多中心、开放标签、双臂Ⅲ期研究(Panc-SELECT——吉西他滨队列)

讲者:Prabhat G. Bhargava|Mumbai, India

摘要号:LBA85

英文标题:HRS-4642 Plus Chemotherapy ± Adebrelimab as Perioperative Therapy in KRAS G12D-Mutant Pancreatic Cancer: Preliminary Results of a Phase 2 Study

中文标题:HRS-4642联合化疗±阿得贝利单抗用于KRAS G12D突变胰腺癌围手术期治疗:一项Ⅱ期研究初步结果

讲者:沈柏用|上海交通大学医学院附属瑞金医院

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